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. 2018 Jul 18;12:140. doi: 10.3389/fnbeh.2018.00140

Figure 3.

Figure 3

Activity of saline- and MPTP-treated WT and KO mice in the open field (A,B), in the open field containing two objects over two subsequent days (C,D), and total time spent exploring the objects (E,F). (A,B) All groups habituated to open field; effect of day; WT: p < 0.001; KO: p < 0.001. WT mice treated with MPTP traveled more distance than saline-treated WT mice. bp = 0.043. WT and KO females moved more than genotype-matched males in the open field. WT: ap = 0.001; KO: ap < 0.001. (C,D) WT MPTP-treated mice moved more than saline mice in the open field containing two objects (p = 0.004). WT and KO saline-treated mice moved less on the second day than the first day in the open field containing two objects. WT: ^p = 0.024; KO: ^p = 0.04. KO females moved more overall than KO males. ap = 0.038). (E,F) In WT mice, MPTP increased the time the mice spent exploring the objects. bp = 0.034. # refers to an interaction between sex and day (F(2,84) = 3.880; p = 0.024).