Figure 1.

PKC mediates LPS-induced monocyte adhesion. (A) THP-1 cells were incubated with 1 μg/mL LPS for different times and culture plate adhesion was measured (n = 4). (B) Effect of LPS on PKC activity in the presence or absence of 10⁻⁶ M Wortmannin (n = 5). (C) The effect of 10⁻⁶ M calphostin C and 10⁻⁶ M Wortmannin on LPS- or PMA-induced THP-1 cell adhesion (n = 3). PKC, protein kinase C; Calph C, calphostin C; Wort, wortmannin. The results are presented as means ± SE. *p < 0.05 vs. unstimulated non-adhered cells (control); #p < 0.05 vs. LPS.