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mTORC1 mediates cytoskeleton rearrangement in LPS-induced monocytes. THP-1 cells pretreated with 10−9 M rapamycin (RAP) or 10−6 M WYE-354 (WYE) before incubation with LPS were allowed to adhere to coverslips coated with 10 μg/mL fibronectin followed by F-actin staining by phalloidin-Alexa Fluor 546 (red color) and DAPI (blue color). (a–c) control, (d–f) LPS, (g–i) LPS + rapamycin, (j–l) LPS + WYE-354. Cells were examined by microscopy with 40 × objective. Scale bar, 10 μm (n = 3).
