Table 2.
MIC and MFC values in µg/mL (µM/L) of [CoCl2(dap)2]Cl (1), [CoCl2(en)2]Cl (2), amphotericin B and ketoconazole against Candida strains.
| Strains | [CoCl2(dap)2]Cl (1) | [CoCl2(en)2]C (2) | Amphotericin B | Ketoconazole | ||||
|---|---|---|---|---|---|---|---|---|
| MIC | MFC | MIC | MFC | MIC | MFC | MIC | MFC | |
| C. albicans ATCC 10231 | 62.5 ± 4.95 | 125 ± 9.89 | 62.5 ± 4.039 | 125 ± 8.08 | 0.5 ± 0.06 | 0.5 ± 0.08 | >128 | >128 |
| (179) | (715) | (276) | (552) | (0.54) | (0.54) | >(241) | >(241) | |
| C. albicans 12823 | 62.5 ± 4.04 | 250 ± 16.16 | 62.5 ± 4.95 | 250 ± 19.79 | 0.5 ± 0.06 | >128 | 128 ± 16.54 | >128 |
| (179) | (720) | (276) | (1104) | (0.54) | >(241) | (241) | >(241) | |
| C. albicans FluR96 | 62.5 ± 4.95 | 250 ± 16.16 | 125 ± 8.08 | 500 ± 32.31 | 1 ± 0.06 | 2 ± 0.13 | 128 ± 16.54 | >128 |
| (179) | (720) | (552) | (2210) | (1.1) | (2.2) | (241) | >(241) | |
| C. albicans FluS79 | 62.5 ± 4.04 | 125 ± 16.16 | 125 ± 9.89 | 500 ± 32.31 | 2 ± 0.16 | 4 ± 0.52 | >128 | >128 |
| (179) | (715) | (552) | (2210) | (2.2) | (4.3) | (241) | >(241) | |
| C. albicans FluS81 | 62.5 ± 8.08 | 125 ± 9.89 | 125 ± 8.08 | 250 ± 16.16 | 1 ± 0.13 | 2 ± 0.27 | 128 ± 16.54 | >128 |
| (179) | (715) | (552) | (11040) | (1.1) | (2.2) | (241) | >(241) | |
| C. albicans 12588 | 16 ± 1.97 | 250 ± 32.31 | 62.5 ± 8.08 | 1000 ± 64.63 | 0.5 ± 0.08 | 0.5 ± 0.07 | >128 | >128 |
| (4.6) | (720) | (276) | (4420) | (0.54) | (0.54) | >(241) | >(241) | |
| C. albicans 12900 | 125 ± 8.08 | 500 ± 32.31 | 125 ± 9.89 | 1000 ± 79.15 | 2 ± 0.16 | 4 ± 0.26 | 128 ± 20.26 | >128 |
| (715) | (1430) | (552) | (4420) | (2.2) | (4.3) | (241) | >(241) | |
| C. albicans 1600/1 | 62.5 ± 8.08 | 250 ± 32.31 | 125 ± 9.89 | 250 ± 39.58 | 0.125 ± 0.02 | 0.5 ± 0.04 | >128 | >128 |
| (179) | (720) | (552) | (1104) | (0.14) | (0.27) | >(241) | >(241) | |
| C. glabrata ATCC 2001 | 16 ± 1.97 | 62.5 ± 8.08 | 16 ± 2.41 | 62.5 ± 8.08 | 0.25 ± 0.02 | 0.5 ± 0.06 | 64 ± 5.07 | 128 ± 16.54 |
| (4.6) | (179) | (70.6) | (276) | (0.27) | (0.54) | (120) | (241) | |
| C. glabrata 11644 | 16 ± 2.41 | 31.25 ± 4.04 | 16 ± 1.97 | 31.25 ± 4.04 | 0.5 ± 0.04 | 2 ± 0.13 | 64 ± 4.14 | >128 |
| (4.6) | (89) | (70.6) | (380) | (0.54) | (2.2) | (120) | >(241) | |
| C. glabrata DSM 11226 | 31.25 ± 4.04 | 125 ± 18.66 | 62.5 ± 6.35 | 250 ± 32.31 | 0.5 ± 0.04 | 1 ± 0.13 | 128 ± 10.13 | >128 |
| (89) | (715) | (276) | (1104) | (0.54) | (1.1) | (241) | >(241) | |
| C. krusei ATCC6258 | 62.5 ± 4.95 | 125 ± 16.16 | 62.5 ± 4.04 | 250 ± 32.31 | 2 ± 0.16 | 4 ± 0.63 | 128 ± 8.27 | >128 |
| (179) | (715) | (276) | (104) | (2.2) | (4.3) | (241) | >(241) | |
| C. krusei FluS59 | 62.5 ± 4.04 | 125 ± 16.16 | 62.5 ± 4.95 | 125 ± 8.08 | 2 ± 0.16 | 8 ± 0.63 | 128 ± 10.13 | >128 |
| (179) | (715) | (276) | (552) | (2.2) | (8.7) | (241) | >(241) | |
| C. krusei FluR176 | 62.5 ± 4.95 | 62.5 ± 4.95 | 62.5 ± 4.95 | 62.5 ± 4.04 | 1 ± 0.13 | 4 ± 0.26 | 128 ± 8.27 | >128 |
| (179) | (179) | (276) | (276) | (1.1) | (4.3) | (241) | >(241) | |
| C. tropicalis 12946 | 31.25 ± 4.04 | 125 ± 9.89 | 31.25 ± 4.04 | 250 ± 16.16 | 1 ± 0.16 | 4 ± 0.26 | 128 ± 8.27 | >128 |
| (89) | (715) | (138) | (1104) | (1.1) | (4.3) | (241) | >(241) | |
| C. parapsilosis ATCC 22019 | 125 ± 9.89 | 500 ± 39.58 | 250 ± 16.16 | 1000 ± 79.15 | 2 ± 0.13 | 4 ± 0.52 | 32 ± 5.07 | 64 ± 8.27 |
| (715) | (1430) | (1103) | (4420) | (2.2) | (4.3) | (60) | (241) | |
| C. lusitaniae | 62.5 ± 8.08 | 500 ± 39.57 | 125 ± 16.16 | 500 ± 32.31 | 2 ± 0.16 | 4 ± 0.52 | 128 ± 10.13 | >128 |
| (179) | (1430) | (552) | (2210) | (2.2) | (4.3) | (241) | >(241) | |
Data shown are mean ± SD.