Table 3.
Fractional inhibitory concentration index (FICi) values of [CoCl2(dap)2]Cl (1), amphotericin B and ketoconazole.
| Strains | Origin | Antifungal agent | MIC of Antifungal agent (µg/mL) | MIC of (1) (µg/mL) | FICi | Outcome | ||
|---|---|---|---|---|---|---|---|---|
| Alone | Com. | Alone | Comb. | |||||
| Candida albicans | Reference | Amphotericin B | 0.5 | 0.125 | 62.5 | 31.25 | 0.63 | No interaction |
| ATCC 10231 | Ketoconazole | 256 | 2 | 62.5 | 31.25 | 0.51 | Synergy | |
| Candida albicans | Clinical | Amphotericin B | 0.5 | 0.125 | 62.5 | 16 | 0.76 | No interaction |
| 12823 | Ketoconazole | 128 | 1 | 62.5 | 16 | 0.26 | Synergy | |
| Candida glabrata | Reference | Amphotericin B | 0.25 | 0.25 | 16 | 31.25 | 2.0 | No interaction |
| ATCC 2001 | Ketoconazole | 64 | >128 | 16 | 31.25 | 2.0 | No interaction | |
| Candida glabrata | Clinical | Amphotericin B | 0.5 | 0.25 | 16 | 7.8 | 1.49 | No interaction |
| 11644 | Ketoconazole | 64 | 16 | 16 | 7.8 | 0.74 | No interaction | |
| Candia krusei | Reference | Amphotericin B | 2 | 0.25 | 62.5 | 31.25 | 0.75 | No interaction |
| ATCC 6258 | Ketoconazole | 128 | 1 | 62.5 | 16 | 0.26 | Synergy | |
| Candida krusei | Clinical | Amphotericin B | 2 | 0.5 | 62.5 | 31.25 | 1.05 | No interaction |
| FluS59 | Ketoconazole | 128 | 4 | 62.5 | 16 | 0.29 | Synergy | |
| Candida krusei | Reference | Amphotericin B | 1 | 0.125 | 62.5 | 16 | 0.76 | No interaction |
| FluR176 | Ketoconazole | 128 | 32 | 62.5 | 16 | 0.50 | Synergy | |
| Candida tropicalis | Clinical | Amphotericin B | 1 | 0.5 | 31.25 | 16 | 1.5 | No interaction |
| Ketoconazole | 128 | 2 | 31.25 | 16 | 0.51 | Synergy | ||