Table 5.
MIC (µg/mL) values in the presence of sorbitol and ergosterol against different strains of Candida spp.
| Strain | Compound | Sorbitol | Ergosterol | |||
|---|---|---|---|---|---|---|
| Absence | Presence | Absence | Presence | |||
| 2 d∗ | 7 d∗ | |||||
| C. albicans ATCC 10231 | [CoCl2(dap)2]Cl (1) | 62.5 ± 4.95 | 62.5 ± 4.95 | 125 ± 8.08 | 62.5 ± 4.04 | 62.5 ± 4.95 |
| [CoCl2(en)2]Cl (2) | 62.5 ± 8.08 | 125 ± 9.98 | 125 ± 9.89 | 62.5 ± 4.04 | 62.5 ± 8.08 | |
| Amphotericin B | – | – | – | 0.5 ± 0.04 | 64 ± 4.13 | |
| C. albicans 12823 | [CoCl2(dap)2]Cl (1) | 62.5 ± 4.04 | 125 ± 9.98 | 250 ± 16.16 | 62.5 ± 4.04 | 125 ± 9.89 |
| [CoCl2(en)2]Cl (2) | 62.5 ± 4.95 | 250 ± 19.79 | 250 ± 19.79 | 62.5 ± 4.95 | 125 ± 8.08 | |
| Amphotericin B | – | – | – | 0.5 ± 006 | 64 ± 5.07 | |
| C. glabrata ATCC 2001 | [CoCl2(dap)2]Cl (1) | 16 ± 1.97 | 31.25 ± 1.97 | 62.5 ± 8.47 | 16 ± 2.41 | 16 ± 1.97 |
| [CoCl2(en)2]Cl (2) | 16 ± 1.29 | 31.25 ± 4.04 | 62.5 ± 4.95 | 16 ± 2.41 | 16 ± 2.41 | |
| Amphotericin B | – | – | – | 0.25 ± 0.02 | 32 ± 2.53 | |
| C. glabrata 11644 | [CoCl2(dap)2]Cl (1) | 16 ± 1.06 | 31.25 ± 1.97 | 62.5 ± 8.47 | 16 ± 1.06 | 16 ± 1.06 |
| [CoCl2(en)2]Cl (2) | 16 ± 1.97 | 31.25 ± 1.97 | 62.5 ± 4.95 | 16 ± 2.41 | 16 ± 1.97 | |
| Amphotericin B | – | – | 0.5 ± 0.04 | 64 ± 8.27 | ||
| C. krusei ATCC 6259 | [CoCl2(dap)2]Cl (1) | 62.5 ± 8.47 | 125 ± 16.16 | 125 ± 8.08 | 62.5 ± 4.04 | 125 ± 8.08 |
| [CoCl2(en)2]Cl (2) | 62.5 ± 4.04 | 125 ± 8.08 | 125 ± 9.89 | 62.5 ± 4.95 | 125 ± 9.89 | |
| Amphotericin B | – | – | – | 2 ± 0.16 | 64 ± 4.13 | |
| C. krusei FluS59 | [CoCl2(dap)2]Cl (1) | 62.5 ± 4.04 | 62.5 ± 8.47 | 62.5 ± 4.04 | 62.5 ± 4.04 | 125 ± 8.08 |
| [CoCl2(en)2]Cl (2) | 62.5 ± 8.47 | 62.5 ± 4.95 | 125 ± 9.89 | 62.5 ± 4.95 | 125 ± 16.16 | |
| Amphotericin B | – | – | – | 2 ± 0.32 | >128 | |
∗d, day. Data shown are mean ± SD.