Table 3.
Risk of recurrent venous thrombosis by use of statins
| PY | Events | Age and sex adjusted | Multivariable adjusted | Propensity score adjusted | |
|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| Venous thrombosis | |||||
| No use | 11551 | 335 | 1 (reference) | 1 (reference) | 1 (reference) |
| Prevalent + new use | 1071 | 32 | 0.86 (0.60‐1.25) | 0.89 (0.61‐1.30) | 0.92 (0.62‐1.35) |
| New use | 603 | 16 | 0.76 (0.46‐1.26) | 0.78 (0.46‐1.31) | 0.87 (0.52‐1.47) |
| Deep vein thrombosis | |||||
| No use | 6700 | 207 | 1 (reference) | 1 (reference) | 1 (reference) |
| Prevalent + new use | 530 | 17 | 0.90 (0.55‐1.48) | 0.89 (0.52‐1.51) | 0.91 (0.52‐1.57) |
| New use | 290 | 7 | 0.70 (0.33‐1.49) | 0.66 (0.29‐1.48) | 0.75 (0.33‐1.71) |
| Pulmonary embolism | |||||
| No use | 4851 | 128 | 1 (reference) | 1 (reference) | 1 (reference) |
| Prevalent + new use | 541 | 15 | 0.86 (0.49‐1.47) | 0.91 (0.52‐1.56) | 0.96 (0.55‐1.66) |
| New use | 313 | 9 | 0.85 (0.43‐1.69) | 0.91 (0.46‐1.80) | 1.00 (0.50‐1.98) |
| Unprovoked | |||||
| No use | 3222 | 145 | 1 (reference) | 1 (reference) | 1 (reference) |
| Prevalent + new use | 423 | 17 | 0.92 (0.55‐1.53) | 0.96 (0.57‐1.63) | 0.93 (0.55‐1.57) |
| New use | 242 | 11 | 1.04 (0.56‐1.92) | 1.03 (0.54‐1.98) | 1.04 (0.54‐2.00) |
| Provoked | |||||
| No use | 8094 | 182 | 1 (reference) | 1 (reference) | 1 (reference) |
| Prevalent + new use | 611 | 14 | 0.79 (0.45‐1.37) | 0.77 (0.43‐1.36) | 0.89 (0.50‐1.58) |
| New use | 349 | 5 | 0.50 (0.20‐1.21) | 0.53 (0.22‐1.29) | 0.64 (0.27‐1.58) |
CI, confidence interval; HR, hazard ratio; PY, person years; Multivariable model: age, sex, body mass index and smoking.