Table 4.
Rates of VTE recurrences and major bleeding, according to the presence of age ≥75 years, CrCl ≤50 mL/min and/or body weight ≤50 kg
| N | VTE recurrences | Major bleeding | |||
|---|---|---|---|---|---|
| N (%) | OR (95% CI) | N (%) | OR (95% CI) | ||
| Non‐fragile | 8819 | 123 (1.4%) | Ref. | 124 (1.4%) | Ref. |
| Age ≥75 years only | 2967 | 22 (0.7%) | 0.5 (0.3‐0.8) | 62 (2.1%) | 1.5 (1.1‐2.0) |
| CrCl ≤50 mL/min only | 521 | 6 (1.2%) | 0.8 (0.3‐1.8) | 23 (4.4%) | 3.2 (2.0‐5.0) |
| Body weight ≤50 kg only | 183 | 3 (1.6%) | 1.2 (0.3‐3.3) | 2 (1.1%) | 0.8 (0.1‐2.6) |
| Age ≥75 years and CrCl ≤50 mL/min | 2235 | 16 (0.7%) | 0.5 (0.3‐0.8) | 60 (2.7%) | 1.9 (1.4‐2.6) |
| Age ≥75 years and body weight ≤50 kg | 51 | 0 | — | 1 (2.0%) | 1.4 (0.1‐7.3) |
| CrCl ≤50 mL/min and weight ≤50 kg | 42 | 1 (2.4%) | 1.7 (0.1‐9.0) | 2 (4.8%) | 3.5 (0.6‐12.4) |
| All 3 conditions | 261 | 1 (0.4%) | 0.3 (0.01‐1.4) | 12 (4.6%) | 3.4 (1.8‐6.0) |
CI, confidence intervals; CrCl, creatinine clearance; OR, odds ratio; Ref., reference; VTE, venous thromboembolism.