Figure 2.

Potential mechanisms involved in progression of liver disease by intrahepatic activation of hemostasis. (A) Intrahepatic activation of endothelial cells results in the formation of platelet microthrombi in the sinusoid. Such microthrombi result in disease progression via the results of microischemia of the downstream tissue. (B) Hepatocellular injury results in decryption of hepatocyte tissue factor, the generation of thrombin (IIa), and eventually fibrin deposition in the sinusoid. (C) Concomitant activation of hepatocytes and hepatic endothelium results in the formation of platelet and fibrin‐containing microthrombi in the sinusoid. (D) Thrombin generated via decryption of hepatocyte tissue factor activates hepatic stellate cells to synthesize collagen