Figure 4.

Results of VEGFR‐2 detection by immunohistochemistry. No expression of VEGFR‐2 was detected on Merkel cell carcinoma cells. (A): Variable, strong to minimal, VEGFR‐2 staining intensity was present in intratumoral vessels. (B): Paired pre‐cabozantinib (upper row) and on‐treatment (lower row) samples showed no appreciable changes in intensity or extent of VEGFR‐2 staining in intratumoral vessels. (C): Vessels within the tumor and away from the tumor, nonmalignant surrounding tissue. The proportion of positive vessels and staining intensity was markedly increased in intratumoral vessels (left) compared with vessels in adjacent benign tissue (right).