Figure 2.

Dramatic response to ramucirumab plus paclitaxel in two patients with advanced gastroesophageal junction adenocarcinoma. (A): Case 1: Baseline computed tomography (CT) scan shows a 15‐cm confluent hepatic mass involving the left and caudate lobes. The mass abuts the lesser curvature of the stomach where the loss of the fat plane between the liver and stomach (arrowheads) corresponds to the patient's worsening epigastric discomfort and suggests direct invasion. Not shown are enlarged upper abdominal lymph nodes. Subsequent scans after treatment show shrinkage of all metastatic lesions and restoration of the fat plane, corresponding to resolution of symptoms. Complete radiographic response is evident after 13 months of therapy. (B): Case 2: Complete metabolic resolution of fluorodeoxyglucose‐avid testicular metastases on positron emission tomography and CT scan after treatment, corresponding to resolution of the metastases on clinical exam.