Table 2.
Top 10 Braak stage DMCGs plus 25 selected CpGs from 200 top entries
| Rank | P value (meta-analysis) | P value (neuron) | P value (glia) | TargetID | Chr | Position | Gene | Region | Probe SNPs | FDR |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1.50E−13 | 1.15E−06 | 3.83E−09 | cg06549928 | 1 | 89990868 | LRRC8B | 5UTR | 7.17624E−08 | |
| 2 | 6.43E−11 | 4.64E−06 | 4.98E−07 | cg21913630 | 7 | 128828599 | SMO | TSS200 | 1.53811E−05 | |
| 3 | 2.05E−10 | 3.04E−05 | 2.54E−07 | cg16562251 | 1 | 166845621 | TADA1 | 1stExon | 3.26918E−05 | |
| 4 | 2.90E−10 | 1.15E−05 | 9.63E−07 | cg08738571 | 12 | 32655192 | FGD4 | 1stExon | rs56168193 | 3.45416E−05 |
| 5 | 3.61E−10 | 9.00E−06 | 1.54E−06 | cg22140756 | 2 | 177895827 | 3.45416E−05 | |||
| 6 | 4.81E−10 | 7.42E−06 | 2.52E−06 | cg04913265 | 11 | 133939627 | JAM3 | Body | 3.8353E−05 | |
| 7 | 8.78E−10 | 1.69E−05 | 2.07E−06 | cg20693608 | 4 | 113152836 | AP1AR | TSS200 | 6.0007E−05 | |
| 8 | 1.57E−09 | 7.82E−06 | 8.20E−06 | cg24449302 | 15 | 66679100 | MAP2K1 | TSS200 | rs77540803 | 7.02674E−05 |
| 9 | 1.60E−09 | 7.69E−06 | 8.51E−06 | cg13172549 | 7 | 27153636 | HOXA3 | 5UTR | 7.02674E−05 | |
| 10 | 1.61E−09 | 2.63E−06 | 2.50E−05 | cg04547723 | 14 | 75421960 | PGF | 5UTR | 7.02674E−05 | |
| 11 | 1.67E−09 | 1.49E−05 | 4.58E−06 | cg07835289 | 1 | 236030215 | LYST | 5UTR | 7.02674E−05 | |
| 15 | 2.27E−09 | 0.00021772 | 4.33E−07 | cg11817993 | 14 | 92572978 | ATXN3 | TSS200 | 7.02674E−05 | |
| 21 | 5.19E−09 | 3.14E−05 | 7.12E−06 | cg02037503 | 14 | 23540729 | ACIN1 | 1stExon | 0.000118237 | |
| 27 | 1.04E−08 | 7.43E−05 | 6.24E−06 | cg03040740 | 13 | 99084682 | FARP1 | Body | rs6491426 | 0.000184279 |
| 32 | 1.44E−08 | 0.00087784 | 7.40E−07 | cg13859639 | 11 | 2846716 | KCNQ1 | Body | 0.000215287 | |
| 38 | 2.41E−08 | 0.00041341 | 2.70E−06 | cg03907612 | 6 | 41703314 | TFEB | 5UTR | 0.000303416 | |
| 39 | 2.60E−08 | 7.11E−05 | 1.70E−05 | cg16568373 | 17 | 4853368 | ENO3 | TSS1500 | 0.000318944 | |
| 48 | 3.48E−08 | 2.84E−05 | 5.76E−05 | cg05884192 | 14 | 52515736 | NID2 | Body | rs2516585 | 0.000334891 |
| 53 | 3.75E−08 | 0.00012506 | 1.42E−05 | cg08883485 | 1 | 201619787 | NAV1 | Body | 0.000334891 | |
| 58 | 4.55E−08 | 4.14E−05 | 5.24E−05 | cg23712970 | 14 | 23540735 | ACIN1 | 1stExon | 0.000374624 | |
| 74 | 6.71E−08 | 1.05E−05 | 0.0003106 | cg08843538 | 2 | 210288784 | MAP2 | 1stExon | 0.000429299 | |
| 76 | 6.94E−08 | 4.79E−05 | 7.07E−05 | cg04542489 | 14 | 23775746 | BCL2L2 | TSS1500 | 0.00043306 | |
| 102 | 1.24E−07 | 4.82E−05 | 0.00012891 | cg06355720 | 1 | 153333350 | S100A9 | 3UTR | rs743566 | 0.000581604 |
| 103 | 1.27E−07 | 5.37E−05 | 0.00011905 | cg26327118 | 6 | 39693366 | KIF6 | TSS200 | 0.000589892 | |
| 104 | 1.31E−07 | 1.08E−05 | 0.00061189 | cg16258854 | 2 | 20648194 | RHOB | 1stExon | rs1062292 | 0.000595763 |
| 111 | 1.41E−07 | 0.00052315 | 1.36E−05 | cg08866780 | 21 | 27543523 | APP | TSS1500 | 0.000604315 | |
| 112 | 1.42E−07 | 0.01466411 | 4.90E−07 | cg03613822 | 17 | 7115140 | DLG4 | Body | 0.000604315 | |
| 126 | 1.71E−07 | 5.41E−06 | 0.00161641 | cg06291595 | 14 | 74960292 | NPC2 | TSS1500 | 0.000646609 | |
| 131 | 1.86E−07 | 0.01071281 | 8.90E−07 | cg04153489 | 8 | 41655983 | ANK1 | TSS1500 | 0.000679278 | |
| 133 | 1.99E−07 | 2.07E−05 | 0.00049571 | cg19447671 | 2 | 176032513 | ATF2 | 5UTR | 0.000715825 | |
| 134 | 2.04E−07 | 0.00058734 | 1.79E−05 | cg10313337 | 16 | 68823690 | CDH1 | Body | 0.000728335 | |
| 141 | 2.18E−07 | 0.00020684 | 5.47E−05 | cg01015899 | 12 | 120663812 | PXN | 5UTR | 0.000737839 | |
| 152 | 2.41E−07 | 2.45E−05 | 0.00051347 | cg27212541 | 3 | 49507385 | DAG1 | TSS200 | 0.00075801 | |
| 161 | 2.68E−07 | 0.00027187 | 5.17E−05 | cg07745886 | 8 | 42150794 | IKBKB | Body | 0.000796369 | |
| 199 | 4.19E−07 | 0.00095868 | 2.35E−05 | cg01231165 | 2 | 9695142 | ADAM17 | Body | 0.001001966 |