Table 2.

Associations between AF/AFL and 3-year survival in PAH/CTEPH patients.

	Hazard Ratio	95% CI	p-value
Unadjusted	3.81	(2.64, 5.52)	<0.001
Adjusted for clinical covariates*	3.75	(2.51, 5.59)	<0.001
Adjusted for RHC parameters**	4.08	(2.77, 6.00)	<0.001
Adjusted for echo parameters***	4.17	(2.75, 6.31)	<0.001
Adjusted for median follow-up heart rate****	3.90	(2.69, 5.65)	<0.001
Adjusted for max follow-up heart Rate****	3.93	(2.71, 5.69)	<0.001

^*Adjusted for age, gender, BMI, smoking status, SBP, CHF, Diabetes, COPD, OSA

^**Adjusted for mPAP, PCWP, sPAP, CO, and PVR

^***Adjusted for LVEF, RAA, LAVI, E/E’, Mitral flow deceleration time, and DD grade

^****Adjusted for follow-up heart rate

Sensitivity analysis #1: PAH only (excluding CTEPH)

Unadjusted HR = 4.05, 95% CI (2.74–5.99), p < 0.001

Sensitivity analysis #2: Paroxysmal AF/AFL only

Unadjusted HR = 4.67, 95% CI (2.83–7.70), p < 0.001

Sensitivity analysis #3: Non-paroxysmal AF/AFL only

Unadjusted HR = 3.11, 95% CI (1.96–4.93), p < 0.001