Table 2.
Pharmacokinetic parameter estimations of CIS in plasma of normal balb/c mice after being treated with 2CIS2 (4 mg/kg, IV) through a tail vein and 2CIS2 (4 mg/kg, SC), 2DTX2/CIS2 (4 mg/kg each, SC), P13L0.15O1.52D2C2 (4 mg/kg each, SC), 2DTX1/CIS1 (2 mg/kg each, SC), and P13L0.15O1.52D1C1 (2 mg/kg each, SC).
| Parameters | 2CIS2 (IV) | 2CIS2 (SC) | 2DTX2/CIS2 | P13L0.15O1.52D2C2 | 2DTX1/CIS1 | P13L0.15O1.52D1C1 |
|---|---|---|---|---|---|---|
| AUC0–72 (ng/h/mL) | 35,030.66 (3817.203) | 31,398.67 (1941.69) | 35,684.62 (2738.70) | 33,273.03 (6790.87) | 19,090.21 (1003.34) | 18,396.05 (3127.88) |
| AUC0–inf (ng/h/mL) | 48,701.88 (7414.28) | 65,844.12 (40,991.26) | 51,110.11 (469.51) | 65,781.19 (5658.28) | 27,883.53 (2270.33) | 36,781.17 (15,477.15) |
| Cmax (ng/mL) | 1558.51 (330.03) | 1320.87 (655.35) | 932.62 (250.07) | 906.87 (92.68) | 561.59 (45.50) | 531.64 (91.11) |
| Tmax (h) | 0.5 (0.00) | 0.5 (0.00) | 2.17 (2.46) | 2.00 (2.60) | 0.5 (0.00) | 0.67 (0.29) |
| T1/2 (h) | 37.63 (12.40) | 75.24 (61.61) | 42.12 (7.25) | 70.06 (9.46) | 42.97 (9.78) | 66.83 (27.03) |
| CL (mL/h/kg) | 83.32 (11.68) | 76.34 (38.80) | 78.27 (0.722) | 39.57 (34.51) | 72.04 (5.70) | 60.11 (20.48) |
| V (mL/kg) | 4440.05 (1328.08) | 6123.76 (1212.61) | 4751.30 (779.98) | 4235.26 (3810.24) | 4416.04 (658.35) | 5303.11 (945.78) |
| MRT (h) | 28.26 (1.27) | 29.99 (1.74) | 29.02 (0.63) | 21.16 (16.18) | 28.97 (0.85) | 30.00 (1.99) |
Parameters are defined in the footnotes to Table 1.