Table 3.
Observed responses for the Box–Behnken design..
| Std/Run | Independent variables |
Dependent variables |
|||||
|---|---|---|---|---|---|---|---|
| Mode | X1 | X2 | X3 | Y1 | Y2 | Y3 | |
| 9/7 | 0/−1/−1 | 4 | 1.8 | 6 | 38.26 | 97.06 | 0.0564 |
| 10/5 | 0/+1/−1 | 4 | 2.2 | 6 | 24.31 | 82.65 | 0.0458 |
| 11/3 | 0/−1/+1 | 4 | 1.8 | 14 | 33.45 | 94.78 | 0.0711 |
| 12/15 | 0/+1/+1 | 4 | 2.2 | 14 | 17.89 | 68.54 | 0.0688 |
| 5/4 | −1/0/−1 | 2 | 2.0 | 6 | 37.12 | 98.04 | 0.0419 |
| 6/12 | +1/0/−1 | 6 | 2.0 | 6 | 42.90 | 98.58 | 0.0520 |
| 7/16 | −1/0/+1 | 2 | 2.0 | 14 | 29.78 | 89.04 | 0.0393 |
| 8/9 | +1/0/+1 | 6 | 2.0 | 14 | 34.67 | 92.35 | 0.0816 |
| 1/17 | −1/−1/0 | 2 | 1.8 | 10 | 35.24 | 96.87 | 0.0459 |
| 2/2 | +1/−1/0 | 6 | 1.8 | 10 | 40.03 | 98.96 | 0.0774 |
| 3/1 | −1/+1/0 | 2 | 2.2 | 10 | 15.04 | 62.18 | 0.0297 |
| 4/10 | +1/+1/0 | 6 | 2.2 | 10 | 20.56 | 70.63 | 0.0806 |
| 14/6 | 0/0/0 | 4 | 2.0 | 10 | 19.48 | 85.74 | 0.0823 |
| 17/8 | 0/0/0 | 4 | 2.0 | 10 | 18.33 | 83.66 | 0.0659 |
| 16/11 | 0/0/0 | 4 | 2.0 | 10 | 19.09 | 84.79 | 0.0741 |
| 15/13 | 0/0/0 | 4 | 2.0 | 10 | 18.97 | 85.27 | 0.0692 |
| 13/14 | 0/0/0 | 4 | 2.0 | 10 | 19.20 | 82.23 | 0.0781 |
X1 is the factor of strength of the preparation, X2 is the factor of CS amount, X3 is the factor of GP content, Y1 is the response of cumulative release percentage of PYM in 1 day, Y2 is the response of cumulative release percentage PYM in 9 days, Y3 is the response of rate constant k.