Table 5.
The analysis of variance for responses Y1, Y2 and Y3.
| ANOVA | Sum of squares |
df |
F-value |
p-value (Prob > F) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y1 | Y2 | Y3 | Y1 | Y2 | Y3 | Y1 | Y2 | Y3 | Y1 | Y2 | Y3 | |
| Model | 908.5 | 2046.38 | 4.29E-03 | 9 | 9 | 9 | 46.45 | 20.43 | 11.09 | < .0001 | .0003 | .0022 |
| X1 | 50.85 | 22.41 | 2.27E-03 | 1 | 1 | 1 | 23.4 | 2.01 | 52.8 | .0019 | .1988 | .0002 |
| X2 | 598.23 | 1343.43 | 8.39E-05 | 1 | 1 | 1 | 275.26 | 120.74 | 1.95 | <.0001 | <.0001 | .2054 |
| X3 | 84.44 | 133.01 | 5.23E-04 | 1 | 1 | 1 | 38.85 | 11.95 | 12.16 | .0004 | .0106 | .0102 |
| X1X2 | 0.13 | 10.11 | 9.41E-05 | 1 | 1 | 1 | 0.061 | 0.91 | 2.19 | .8116 | .3722 | .1827 |
| X1X3 | 1.60E-03 | 3.55 | 2.59E-04 | 1 | 1 | 1 | 7.36E-04 | 0.32 | 6.03 | .9791 | .5897 | .0438 |
| X2X3 | 0.65 | 34.99 | 1.72E-05 | 1 | 1 | 1 | 0.3 | 3.14 | 0.4 | .602 | .1195 | .547 |
| X12 | 39.7 | 10.66 | 5.26E-04 | 1 | 1 | 1 | 18.27 | 0.96 | 12.22 | .0037 | .3602 | .0101 |
| X22 | 80.3 | 471.89 | 7.96E-05 | 1 | 1 | 1 | 36.95 | 42.41 | 1.85 | .0005 | .0003 | .216 |
| X32 | 61.78 | 16.94 | 3.45E-04 | 1 | 1 | 1 | 28.43 | 1.52 | 8.01 | .0011 | .257 | .0254 |
| Residual | 15.21 | 77.89 | 3.01E-04 | 7 | 7 | 7 | – | – | – | – | – | – |
| Lack of Fit | 14.49 | 69.95 | 1.27E-04 | 3 | 3 | 3 | 26.56 | 11.74 | 0.97 | .0042 | .0188 | .4894 |
| Pure Error | 0.73 | 7.94 | 1.74E-04 | 4 | 4 | 4 | – | – | – | – | – | – |
| Cor Total | 923.72 | 2124.26 | 4.60E-03 | 16 | 16 | 16 | – | – | – | – | – | – |
X1 is the factor of PYM concentration, X2 is the factor of CS amount, X3 is the factor of GP content, Y1 is the response of cumulative release percentage of PYM in 1 day, Y2 is the response of cumulative release percentage of PYM in 9 days, Y3 is the response of rate constant k.