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Cytotoxicity tests in chondrocyte with various doses of PN-KGN that can maximally release KGN to 0, 10, and 100 nM. The cell numbers were detected by CCK-8 at days 1, 4, and 7 (A). IL-6 secretions from chondrocytes were detected by ELISA after incubation with LPS (1 µg/ml), PN and PN-KGN that can release KGN to 100 nM (B). Data were shown as mean ± SD. N = 3, *p < 0.05.
