Table 1.
Factors studied and respective levels investigated in the 52 full factorial design used for the preparation of proniosomal gel formulations together with the dependent variables and their required constraints.
| Independent variables (Factors) | Levels investigated | ||||
|---|---|---|---|---|---|
| Cholesterol amount (mg) | 60 | 120 | 180 | 240 | 300 |
| Span 40 amount (mg) | 180 | 270 | 360 | 540 | 630 |
| Dependent variables (Responses) |
Constraints |
||||
| Percentage entrapment efficiency (%) (EE%) | Maximize | ||||
| Particle size (nm) (PS) | Minimize | ||||
| Percentage released after 8h (%) (Q8h) | Maximize | ||||