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Ribavirin permeated (% of loaded dose) across rabbit nasal mucosal tissue from μRBV (×), and agglomerates obtained from micronized ribavirin crystals with mannitol/lecithin microparticles AM1 (▪), chitosan/lecithin microparticles AM2 (△) or α-cyclodextrin/lecithin microparticles AM3 (•) (n = 3, average ± SD).
