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Ribavirin distribution in plasma and different brain compartments (OB: olfactory bulb; BG: basal ganglia; Hip: hippocampus; CTX Ant: anterior cortex; CTX Post: posterior cortex; CRB: cerebellum) after the nasal administration of micronized ribavirin crystals (white bars) or agglomerates obtained with micronized ribavirin and α-cyclodextrin/lecithin microparticles (AM3) (black bars) (n = 6, average ± SEM).
