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. 2018 May 4;25(1):1013–1024. doi: 10.1080/10717544.2018.1464082

Figure 1.

Figure 1.

Physicochemical characterization of GKRK-APO. Binding of Cy5.5-labeled APO or Cy5.5-labeled GKRK-APO to immobilized HSPG integrin was assessed by measuring the fluorescence of the wells following washing to remove unbound samples (A). Binding of Cy5.5-labeled GKRK-APO (2 μM) to immobilized HSPG was significantly inhibited by the free GKRK peptide in a dose-dependent manner (B). In vitro release of VCR from GKRK-APO and APO at pH 5.0 and pH 7.0 at 37 °C, respectively (C). Particle size distribution of VCRloaded GKRK-APO (D). Morphological appearance of VCR-loaded GKRK-APO based on TEM (E) and AFM (F). Stability of VCR-loaded GKRK-APO in the presence of 10% FBS. The transmission and backscattering profiles were measured at each time point using a Turbiscan Lab® Expert analyser (G). The data are presented as the means ± SD (n = 3). * indicates P< 0.05.