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. 2018 Jul 11;25(1):1526–1536. doi: 10.1080/10717544.2018.1482970

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Photo cytotoxicity and dose-dependent effect of PpIX in SKOV-3 (A) and L929 (B) cells. After incubation with TEL_9mol% liposomes (a₁ and b₁) or TEL_62mol% (a₂ and b₂) liposomes at TL: PpIX 10 (t_PpIX = 3h), cells were light irradiated at a series of radiant exposure doses of 134, 202, 403 and 672mJ.cm⁻² (irradiance = 22 W.m⁻²). Cell survival is represented as a percentage of control-cell growth in cultures containing no PpIX. Cell proliferation was quantified colorimetrically using MTT assay. Half-maximal inhibitory concentrations (IC₅₀) for PpIX were calculated from the fitted dose–response curves. In graph a₃, elevated generation of singlet oxygen in SKOV-3 after various cPDT treatments with PpIX at the same radiant exposure doses is presented. Each point represents the mean of quintuplicates (n = 5) ±SD of three separate experiments; ***p < .001.