Table 3.
Pharmacokinetic parameters of curcumin following oral administration of free Cur and Cur SD.
| Parameters | Free Cur (control) | Cur SD 1:1 | Cur SD 1:2 | Cur SD 1:4 |
|---|---|---|---|---|
| Cmax (μg/mL) | 1.48 ± 0.03 | 9.04 ± 0.35** | 17.68 ± 0.22** | 29.87 ± 2.71** |
| Tmax (min) | 15 ± 0.00 | 5 ± 0.00 | 5 ± 0.00 | 15 ± 0.00 |
| T1/2 (h) | 5.07 ± 0.41 | 8.02 ± 0.70** | 9.05 ± 0.65** | 11.16 ± 1.03** |
| AUC0→t (μg/mL.h) | 12.12 ± 0.36 | 64.50 ± 3.12** | 108.16 ± 5.2** | 231.61 ± 10.15** |
| AUC0→inf (μg/mL.h) | 14.26 ± 0.72 | 104.38 ± 6.21** | 181.60 ± 8.76** | 279.50 ± 12.11** |
AUC: area under the plasma concentration–time curve; C max: peak concentration; T max: time to reach peak concentration.
Values are reported as mean ± SEM (n = 5).
**
p < .01 compared with the control.