Table 1:
Experimental runs, independent variables, and measured responses of the 42 full-factorial design for SIL-loaded cubosomes.
| Formulation | P-407a (% w/w) | PVAa (% w/w) | EE (%) | Particle size (nm) | Q8h (%) | PDI |
|---|---|---|---|---|---|---|
| C1 | 5 | 0 | 32.15 ± 2.05 | 446.02 ± 29.81 | 80.19 ± 3.16 | 0.21 |
| C2 | 5 | 1 | 35.89 ± 1.13 | 357.92 ± 20.26 | 76.36 ± 4.32 | 0.10 |
| C3 | 5 | 2.5 | 39.78 ± 2.29 | 308.55 ± 15.57 | 71.97 ± 3.38 | 0.15 |
| C4 | 5 | 5 | 45.81 ± 1.75 | 320.34 ± 19.75 | 61.82 ± 2.86 | 0.18 |
| C5 | 7.5 | 0 | 40.57 ± 2.45 | 252.20 ± 22.36 | 58.58 ± 3.36 | 0.13 |
| C6 | 7.5 | 1 | 53.36 ± 2.03 | 236.60 ± 14.63 | 45.72 ± 3.06 | 0.19 |
| C7 | 7.5 | 2.5 | 56.42 ± 3.24 | 210.04 ± 18.44 | 43.66 ± 2.35 | 0.08 |
| C8 | 7.5 | 5 | 57.28 ± 2. 80 | 227.10 ± 9.11 | 37.53 ± 1.92 | 0.11 |
| C9 | 10 | 0 | 43.84 ± 3.48 | 206.51 ± 10.19 | 52.88 ± 2.59 | 0.12 |
| C10 | 10 | 1 | 46.28 ± 1.40 | 161.54 ± 6.24 | 48.48 ± 2.74 | 0.09 |
| C11 | 10 | 2.5 | 65.89 ± 3.85 | 150.81 ± 6.86 | 44.08 ± 3.05 | 0.14 |
| C12 | 10 | 5 | 66.47 ± 2.76 | 179.50 ± 9.75 | 31.85 ± 2.87 | 0.19 |
| C13 | 15 | 0 | 57.34 ± 1.34 | 249.96 ± 13.10 | 29.09 ± 1.46 | 0.15 |
| C14 | 15 | 1 | 59.63 ± 2.54 | 236.94 ± 18.27 | 25.74 ± 1.30 | 0.13 |
| C15 | 15 | 2.5 | 67.82 ± 4.23 | 229.72 ± 11.39 | 24.12 ± 1.12 | 0.10 |
| C16 | 15 | 5 | 72.01 ± 3.33 | 231.21 ± 17.22 | 21.03 ± 1.41 | 0.20 |
P-407: poloxamer 407; PVA: polyvinyl alcohol.
Concentration of glyceryl monooleate was 5% w/w with respect to the total weight of the dispersion.
Data are mean values (n = 3) ± SD.
a
Concentration with respect to disperse phase.