Table 2.

Pharmacodynamics of insulin in rats with alloxan-induced diabetes.

Formulation	Dose (IU/kg)	AAC0–240 min (% glucose/min)	F%
Insulin alone	2	721.0 ± 478.2	3.2 ± 2.1
+0.25 mM l-TCTP-PTD 13	2	4860.1 ± 424.5	22.4 ± 1.7
+0.25 mM l-TCTP-PTD 13M2	2	9604.5 ± 1204.6	42.3 ± 5.3
Insulin (s.c.)	1	11354.3 ± 507.8	100

Values are expressed as means ± SEM (n = 6–8).

AAC: area above the blood glucose curve; F%: relative pharmacological bioavailability compared to s.c.; s.c.: subcutaneous.