Table 1.

The application of some hyaluronic acid delivery systems.

Dosing system type	Loaded drug	In vivo characteristics
Hyaluronic acid-methylcellulose hydrogel	α-Chymotrypsin, IgG	Slow release of drugs in 28 days
	Nimodipine	Submicron particles with slow release of drug within 2–3 days
Hyaluronic acid microsphere	Recombinant human insulin	Prolongation of retention time and half-life of the drug in vivo
Hyaluronic acid-aminoethyl iso-butylenate nanogel	Insulin, GLP-1, EPO	The drug release was affected by the cross-linking density and degradation rate of the gel, and had the sustained release characteristics
Thiolated hyaluronic acid microhydrogel	EPO	The stable release of drug in 7 days was maintained, and the blood concentration was higher than 0.1 μg/L