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. 2018 Jan 5;25(1):187–197. doi: 10.1080/10717544.2017.1422295

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — MTX–ALN prevented bone erosion and systemic bone loss in the CIA model. (A) Hind paws of rats were scanned with a high-resolution micro-CT. The most severe bone erosion was observed in the control group, while the least severe was shown in the MTX–ALN group. (B) Representative high-resolution micro-CT images of the distal tibia for each rat group. (C) Histomorphometric analysis of the distal tibia for the various treatment groups showing a significant increase in bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular thickness (Tb.Th.), trabecular separation (Tb.Sp.), and trabecular number (Tb.N.) in rats treated with MTX–ALN and ALN; MTX had no effect on histomorphometric parameters. ns, not significant. *p < .05, **p < .01, ***p < .005. NEG: negative control; CG: control; MTX + ALN: free MTX combined with free ALN.