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Experimental design of inhaled vs. IV topotecan for the treatment of lung tumors in rats.
| Group | Lung cancer Cell line | Number of rats | Treatments** |
||
|---|---|---|---|---|---|
| Vehicle | 2 mg/kg IV | 1 mg/kg inhalation | |||
| 1 | None* | 6 | − | − | − |
| 2 | A549 | 15 | + | − | − |
| 3 | 15 | − | + | − | |
| 4 | 15 | − | − | + | |
| 5 | H1975 | 15 | + | − | − |
| 6 | 15 | − | + | − | |
| 7 | 15 | − | − | + | |
Animals in Group 1 serve as cancer-free and treatment-free control.
The ‘+’ and ‘−’ signs indicate the treatments given or not given, respectively.
