Table 2.

Inhaled topotecan is more effective in treating lung cancer than higher IV dose.

Tumors	Group	Treatments	Lung weight (g)	Tumor burden (g)	p Values (versus)
			Mean ± SD	Mean ± SD	Control	IV topotecan
None	1	Naïve (n = 6)	1.6 ± 0.2	–	–	–
A549	2	Vehicle	14.1 ± 2.9	12.6 ± 2.7	–	–
	3	IV topotecan (2 mg/kg) (n = 15)	8.3 ± 2.3	6.7 ± 2.0	1.5E-06*	–
	4	Inhaled topotecan (1 mg/kg) (n = 15)	2.9 ± 0.9	1.3 ± 0.7	8.7E-11*	1.1E-07*
H1975	5	Vehicle	14.3 ± 3.5	12.8 ± 3.3		–
	6	IV topotecan (2 mg/kg) (n = 15)	15.8 ± 2.0	14.3 ± 1.8	1.6E-01	–
	7	Inhaled topotecan (1 mg/kg) (n = 15)	13.4 ± 2.7	11.9 ± 2.5	4.6E-01	1.0E-02

^*Significant differences in tumor-burden between treatment groups.