Figure 1.

Characterization and ROS generation of LIH. (A) Schematic illustration of alleviation of tumor hypoxia and enhanced PDT based on photosensitizer and hemoglobin co-loaded liposomes (LIH). (B) The pO₂ of oxygen saturated Hb and LIH at 24 h determined by oximeter. (C) The photos for the LIH solution (before lyophilization), the powder of LIH (after lyophilization), and the LIH solution (the re-suspended). (D) The diameter of LIH in eight weeks after preparation and the concentration of Hb was found to be 2 mg/ml. (E) TEM images of LI and LIH. Scale bar, 100 nm. (F) ROS generation of LI or LIH exposure to NIR laser in normaxia conditions. (G) ROS generation of LI or LIH exposure to NIR laser in hypoxia conditions.