Table 1.
Antiproliferative efficacy of DAB-Lf dendriplexes encoding TNFα, TRAIL, and IL-12, expressed as IC50 values, in PC-3 and DU145 prostate cancer cells (n.d.: not determined) (n = 15).
| IC50 (µg/mL) (mean ± SEM) | ||||||
|---|---|---|---|---|---|---|
| Formulation | ||||||
| Cell line | DNA | DAB-Lf-DNA | DAB-DNA | DAB-Lf only | DAB only | DNA only |
| PC-3 | TNFα | 9.97 ± 1.38 | 19.50 ± 3.44 | n.d. | n.d. | n.d. |
| TRAIL | 15.62 ± 3.61 | 55.74 ± 22.36 | n.d. | n.d. | n.d. | |
| IL-12 | 10.84 ± 2.71 | 63.33 ± 37.89 | n.d. | n.d. | n.d. | |
| DU145 | TNFα | 4.34 ± 0.68 | 57.38 ± 95.43 | n.d. | n.d. | n.d. |
| TRAIL | 3.03 ± 0.70 | 17.14 ± 3.78 | n.d. | n.d. | n.d. | |
| IL-12 | 3.80 ± 0.97 | 5.92 ± 0.96 | n.d. | n.d. | n.d. | |