Figure 3.

DOX-HA-LPs exhibit a different circulating behavior and a glioma-bearing brains concentrated capability. (a) Ex vivo images showed the drug biodistribution of DOX formulations in C6 glioma-bearing mice at 0.5, 1, 2, and 4 h after intravenous administration; (b) the mean concentrations of DOX in different tissues of C6 glioma-bearing mice after intravenous administration of DOX formulations at 0.5, 1, 2, and 4 h. Data represent mean ± SD (n = 5); (c) in vivo fluorescent microscopy images of brain sections from C6 glioma-bearing mice at 1 h post-injection of DOX and DOX-HA-LPs. TAMs were identified by CD206 marker and nuclei stained with DAPI. Scale bar, 50 μm.