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. 2018 Jan 15;25(1):278–292. doi: 10.1080/10717544.2018.1425776

Figure 2.

Figure 2.

(A) Schematic illustration showing the composition of the degradable deep penetrating cationic nanoparticle (HA/DpNG-PTX, Table 3), and how it can be used to penetrate into tissue; (B) temperature-induced changes in the morphology and association of CHPMA-PNIPAM nanogels and SPL complexes; swollen nanogels formed by the association of a few CHPMA nanogels, shrunken nanogels, and botryoidal nanogels are shown; (C) aqueous condition at 4 °C but hydrogel condition at 37.5 °C is shown; (D) schematic illustration of SpS nanogel under UV–Vis light. HA/DpNG-PTX: hyaluronic acid-coated degradable cationic nanogel–paclitaxel; CHPMA-PNIPAM: methacryloyl-substituted CHP-poly-N-isopropylacrylamide; SPL: succinated pullulan-poly(l-lactide).