Table 2.
Summary of recent studies of nanogel crosslinked hydrogels.
| Hybrid hydrogels | Nanogel/crosslinkers | Loaded objects | Applications | References |
|---|---|---|---|---|
| CHPOA-PEGSH | CHPOA: R: H or Cholesteryl group or AOI(1); PEGSH(2) | Liposome | Dually controlled-release | (Sekine et al., 2012) |
| CHPOA-PEGSH | BMP2 protein, FGF18 protein | Multidrug delivery for bone repair | (Fujioka-Kobayashi et al., 2012) | |
| CHPOA-PEGSH | Insulin | hydrolysis mechanism and exchange reactions | (Shimoda et al., 2012b) | |
| CHPOA-PEGSH | sFGFR2S525W | cytokine therapy | (Yokota et al., 2014) | |
| CHPOA-PEGSH | W9 peptide | Bone repair, sustained-release | (Sato et al., 2015) | |
| CHPOA-PEGSH | Vitronectin, mouse embryo fibroblast cells | Artificial extracellular matrices | (Hashimoto et al., 2016) | |
| CHPOA-PEGSH | Insulin | Longer elimination half-life | (Shimoda et al., 2012a) | |
| CHPOA-PEGSH | Silicone sheet | Wound healing | (Maeda et al., 2017) | |
| CHPA-PEGSH | CHPA: R: H or Cholesteryl group or − COCH = CH2; PEGSH(2) | Prostaglandin E2, BMPprotein, PDGF protein | Bone repair | (Kato et al., 2007; Hayashi et al., 2009; Kamolratanakul et al., 2011; Miyahara et al., 2012) |
| CHPA-PEGSH | Interleukin-12 | Long-term stability | (Hasegawa et al., 2009) | |
| CHPOA-PEGDA | CHPOA; PEGDA(3) | Insulin | Tunable activity | (Tahara et al., 2013) |
| CHPOA-P(MAA-g-EG) | CHPOA; P(MAA-g-EG) | Pregabalin | pH-responsive release | (Cinay et al., 2017) |
| CHPMA-MPC | CHPMA: R: H or Cholesteryl group or − COC(CH3)=CH2; MPC(4) | Insulin, Carbonicanhydrase B | Molecular chaperone | (Morimoto et al., 2005a,b) |
| CHP-HA | CHP: R: H or Cholesteryl group; HA(5) | Peptide-1, insulin, erythropoietin | Molecular chaperone, sustained-release | (Hirakura et al., 2010) |
| PHD | Pullulan-collagen; 1,2,7,8-diepoxyoctane | 1,2,7,8-diepoxyoctane | Tissue filler materials | (Ma et al., 2017) |
AOI: 2-(acryloyloxy)ethyl isocyanate; PEGSH: pentaerythritol tetra (mercaptoethyl)polyoxyethylene; PEGDA: polyrthylene glycol diacrylate; MPC: 2-methacryloyloxyethyl phosphorylcholine; HA: chemically cross-linked Haluronan.
Important structures marked with consecutive numbers (1)–(5) are redrawn within the Supplemental File ‘Numbered Structures’.