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. 2018 Jun 14;25(1):1461–1471. doi: 10.1080/10717544.2018.1482973

Table 1.

Non-compartmental pharmacokinetic parameters of injection site, plasma, popliteal lymph nodes (PLNs), iliac lymph nodes (ILNs) and renal lymph nodes (RLNs) in the SN-38-Lips group and SN-38-Lips group combined with S-BO in the concentrations of 1, 2 and 5 mg/mL following s.c. administration at the dosing of 4 mg/kg (mean ± SD, n = 6).

    SN-38-Lips SN-38-Lips+ SN-38-Lips+ SN-38-Lips+
  1-S-BO 2-S-BO 5-S-BO
    Injection site
AUC0–24 h mg/kg·h 8235.673 6290.983 5496.435 5657.746
AUC0–∞ mg/kg·h 16,269.832 13,223.539 7295.406 10,560.689
MRT0–24 h h 10.659 13.073 9.962 10.547
MRT0–∞ h 34.043 31.302 18.592 33.085
t1/2 h 23.571 16.524 14.524 24.32
CLz/F L/h/kg 0 0 0 0
Tmax h 1 6 4 6
Cmax mg/kg 473.299 312.632 328.568 407.063
    Plasma
AUC0–24 h μg/kg·h 201.643 97.848 290.345 163.285
AUC0–∞ μg/kg·h 228.936 159.59 406.256 163.31
MRT0–24 h h 1.866 3.462 11.387 0.375
MRT0–∞ h 2.685 3.958 12.104 0.375
t1/2 h 1.898 0.516 2.436 0.172
CLz/F L/h/kg 17.472 25.064 9.846 24.493
Tmax h 0.083 4 0.5 0.5
Cmax μg/kg 85.093 77.891 217.385 251.644
    PLNs
AUC0–24 h mg/kg·h 19.619 8.75 66.703 29.632
AUC0–∞ mg/kg·h 20.412 14.127 96.423 30.273
MRT0–24 h h 2.964 4.562 5.803 4.887
MRT0–∞ h 3.448 5.513 9.504 5.423
t1/2 h 2.323 0.355 4.027 4.298
CLz/F L/h/kg 0.196 0.210 0.041 0.132
Tmax h 1 1 1 1
Cmax mg/kg 6.369 2.326 17.413 8.661
    ILNs
AUC0–24 h mg/kg*h 12.818 6.662 117.857 23.099
AUC0–∞ mg/kg*h 13.498 8.633 119.797 39.276
MRT0–24 h h 2.982 4.833 8.023 8.428
MRT0–∞ h 3.630 5.256 8.361 24.511
t1/2 h 2.345 5.422 3.365 14.5
CLz/F L/h/kg 0.296 0.463 0.033 0.102
Tmax h 1 1 6 1
Cmax mg/kg 5.612 1.067 17.726 7.308
    RLNs
AUC0–24 h mg/kg*h 15.773 19.577 163.102 12.049
AUC0–∞ mg/kg*h 35.653 28.307 166.637 13.963
MRT0–24 h h 15.006 10.373 9.125 5.233
MRT0–∞ h 21.116 20.955 9.551 7.002
t1/2 h 15.176 14.334 3.602 4.253
CLz/F L/h/kg 0.112 0.141 0.024 0.286
Tmax h 4 6 6 0.167
Cmax mg/kg 2.722 1.134 18.485 4.631

The following parameters were included AUC: area under the plasma–time curve; MRT: the mean residence time; t1/2: the half-life; V: the distribution volumes of the compartment; CL: clearance; Cmax: maximum plasma concentration; Tmax: time to reach the maximum plasma concentration.