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. 2018 Feb 27;25(1):668–678. doi: 10.1080/10717544.2018.1444683

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — In Vivo antitumor effect of IRE in combination with chemotherapy on nude mice bearing Hep3B xenografts After one treatment. (A) Tumor size over time. (B) Tumor growth ratio over time. Both the IRE and IRE + L-BEZ groups had significantly lower tumor burden than did the control group (one-way ANOVA, p < .05). No statistically significant difference was observed between the IRE and IRE + L-BEZ groups (n = 4 mice per group) (C) Percentage of necrosis as quantified by H&E staining two weeks after one treatment. The median percentage necrosis of combination treatment with IRE + L-BEZ doubled that of IRE treatment alone. Representative H&E-stained slides of tumor treated with IRE alone (D), or IRE + L-BEZ (E). Notice the extent of necrosis exhibited in the tumor treated with the combination therapy compared to that in the tumor treated with IRE alone.