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. 2018 Mar 28;25(1):838–845. doi: 10.1080/10717544.2018.1455762

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — (a) Histogram of the mean intensity of salmeterol determined by MSI per segmented region, i.e. alveolar, sup-epithelium and epithelium, after inhalation or systemic dosing (n = 3) at 30 min after delivery. (b) The mean intensity in each region was normalized against the plasma concentration in respective administration group (n = 3). (c) The targeting factor is the ratio between inhalation and IV group in (b), in respective region, and it describes the gain with inhalation over systemic dosing at equivalent plasma concentrations.