Table 3.
Modelling of failure to complete medications changes
| Univariate models | Multivariate model | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| BNF chapter (2 is reference) | <0.001a | <0.001 | ||||
| BNF chapter 1 (Gastrointestinal) | 9.77 | 5.26 to 18.15 | <0.001 | 8.55 | 4.30 to 16.99 | <0.001 |
| BNF chapter 3 (Respiratory) | 4.93 | 1.47 to 16.58 | 0.010 | 4.16 | 1.15 to 15.06 | 0.030 |
| BNF chapter 4 (CNS) | 6.66 | 3.38 to 13.12 | <0.001 | 7.41 | 3.56 to 15.44 | <0.001 |
| BNF chapter 6 (Endocrine) | 1.93 | 0.61 to 6.08 | 0.264 | 1.39 | 0.42 to 4.62 | 0.590 |
| BNF chapter 7 (Genitourinary) | 5.92 | 1.47 to 23.78 | 0.012 | 3.40 | 0.68 to 17.01 | 0.136 |
| BNF chapter 9 (Nutrition and blood) | 3.29 | 1.32 to 8.18 | 0.010 | 2.06 | 0.77 to 5.52 | 0.150 |
| BNF chapter 10 (Musculoskeletal and Joint) | 6.58 | 1.22 to 35.37 | 0.028 | 5.58 | 0.98 to 31.76 | 0.053 |
| BNF chapter 16 (Dietary supplementsb) | 8.13 | 2.93 to 22.57 | <0.001 | 7.41 | 2.31 to 23.78 | 0.001 |
| BNF chapter other | 7.18 | 2.04 to 25.21 | 0.002 | 8.88 | 2.32 to 34.01 | 0.001 |
| Medication (newly started is reference) | <0.001a | 0.025a | ||||
| Medication stopped | 0.25 | 0.14 to 0.46 | <0.001 | 0.40 | 0.20 to 0.81 | 0.011 |
| Dose changed | 0.70 | 0.40 to 1.21 | 0.201 | 0.81 | 0.41 to 1.61 | 0.553 |
| No reason for medicines change | 1.71 | 1.08 to 2.68 | 0.021 | 1.64 | 0.92 to 2.91 | 0.094 |
| Practice (10 is reference) | 0.043a | c | ||||
| Practice 11 | 0.77 | 0.31 to 1.88 | 0.563 | |||
| Practice 12 | 1.18 | 0.47 to 2.93 | 0.722 | |||
| Practice 13 | 0.83 | 0.33 to 2.07 | 0.686 | |||
| Practice 14 | 1.32 | 0.54 to 3.25 | 0.547 | |||
| Practice 15 | 2.04 | 0.87 to 4.81 | 0.103 | |||
| Practice 16 | 1.29 | 0.53 to 3.18 | 0.574 | |||
| Practice 17 | 0.87 | 0.35 to 2.15 | 0.767 | |||
| Practice 18 | 0.63 | 0.24 to 1.66 | 0.351 | |||
| Practice 19 | 0.40 | 0.14 to 1.18 | 0.097 | |||
| Admission length | 0.99 | 0.98 to 1.00 | 0.011 | 0.99 | 0.98 to 1.00 | 0.150 |
| Days to GP workflow | 1.11 | 0.84 to 1.47 | 0.473 | |||
| Receipt time estimate | 1.01 | 1.00 to 1.01 | 0.023 | 1.01 | 1.00 to 1.02 | 0.003 |
| Specialty surgical | 2.28 | 1.33 to 3.92 | 0.003 | 1.70 | 0.88 to 3.29 | 0.117 |
| GP ratio to population | 1.00 | 1.00 to 1.00 | 0.235 | |||
| Practice size (small is reference) | 0.011a | 0.240a | ||||
| Medium practice size | 0.47 | 0.26 to 0.84 | 0.011 | 0.52 | 0.16 to 1.68 | 0.274 |
| Large practice size | 0.37 | 0.19 to 0.69 | 0.002 | 0.32 | 0.08 to 1.39 | 0.130 |
| EMIS Web IT system | 0.85 | 0.57 to 1.26 | 0.415 | |||
| Training practice status | 0.90 | 0.56 to 1.43 | 0.648 | |||
| IMD of practice | 1.00 | 0.99 to 1.02 | 0.608 | |||
| Urban practice | 0.81 | 0.43 to 1.53 | 0.508 | |||
| QOF score of practice | 0.93 | 0.88 to 0.99 | 0.033 | 1.00 | 0.90 to 1.12 | 0.962 |
| CQC rating | 1.29 | 0.88 to 1.90 | 0.198 | |||
| Patient age | 1.01 | 0.98 to 1.05 | 0.411 | |||
| Patient sex, male | 0.93 | 0.63 to 1.37 | 0.715 | |||
| Number of medicines changes | 0.85 | 0.78 to 0.92 | <0.001 | 0.86 | 0.77 to 0.95 | 0.004 |
| Hospital (Nottingham QMC is reference) | 0.001a | 0.339a | ||||
| Central Manchester Hospital | 0.56 | 0.30 to 1.06 | 0.073 | 0.68 | 0.29 to 1.61 | 0.381 |
| University of Coventry Hospital | 1.69 | 1.06 to 2.69 | 0.029 | 1.07 | 0.46 to 2.51 | 0.868 |
| Other hospitals | 0.36 | 0.13 to 1.03 | 0.058 | 0.38 | 0.11 to 1.32 | 0.129 |
| Follow-up on phone | 1.21 | 0.81 to 1.80 | 0.361 | |||
a
ANOVA P-values are from a likelihood ratio test, the remainder are Wald P-values.
b
For example, Fortisip.
c
Practice variable not included in multivariate model due to confounding with practice size and QOF score. ANOVA = analysis of variance. BNF = British National Formulary. CQC = Care Quality Commission. EMIS = Egton Medical Information Systems. IMD = index of multiple deprivation. OR = odds ratio. QMC = Queen’s Medical Centre. QOF = Quality and Outcomes Framework.