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非小细胞肺癌EGFR、ALK、KRAS突变的不同转移途径及分子机制

Different metastatic pathways and molecular mechanisms of EGFR, ALK and KRAS mutations in non-small cell lung cancer (NSCLC)

Genes	Metastatic sites	Molecular mechanism
EGFR: epidermal growth factor receptor; ALK: anaplastic lymphoma kinase; KRAS: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue.
EGFR	Brain[7-11]	MET gene activation[12];STAT3 signaling pathway activation[13];
	Bone[14, 15]	Increased release of osteoclastic related factors[16];Down-regulation of tumor related factors VEGF-A，VEGFR-1，TNF-α expressions[17];
	Lung[9, 19]	EGFR signaling pathway regulates the synthesis and secretion of vascular endothelial growth factor increased[19]
	Liver[9, 18]	-
ALK	Lymph node[22-24]	-
	Pleura[18, 24, 25]	-
	Brain[26]	-
KRAS	Lung[33]	-
	Brain [31]	LKB1 gene inactivation[31, 32]