Table 2.

Pharmacokinetic parameters of CuD after oral administration of CuB, CuB-MMs, and CuB-MMs-CPs (n = 6).

Parameter	CuB	CuB-MMs	CuB-MMs-CPs
AUC(0-t)/µg h mL−1	3.50 ± 0.77	5.29 ± 0.69	10.69 ± 1.66
AUC(0-∞)/µg h mL−1	3.73 ± 0.97	6.00 ± 1.32	12.81 ± 3.73
MRT/h	6.69 ± 1.36	6.99 ± 0.88	7.77 ± 1.82
C_last/µg mL−1	0.024 ± 0.021	0.052 ± 0.035	0.135 ± 0.035
t1/2/h	5.09 ± 2.20	7.71 ± 3.66	7.71 ± 0.11
Tmax/h	1.08 ± 0.95	1.00 ± 0.71	1.514 ± 0.403
Vz/F/L kg−1	1865.20 ± 441.12	1794.30 ± 591.40	833.08 ± 321.71
CLz/F/L h−1 kg−1	286.22 ± 83.85	172.43 ± 32.43	83.84 ± 24.45
Cmax/µg mL−1	0.40 ± 0.04	0.659 ± 0.036	1.10 ± 0.12