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Response surface plots illustrating the effect of ratio of drug to polymer and ratio of organic to aqueous phase on (a) drug loading and (c) encapsulation efficiency (fixed stirring speed = 250 rpm), ratio of organic to aqueous phase and stirring speed on (b) drug loading and (d) encapsulation efficiency (fixed ratio of drug to polymer =1:1.8), ratio of drug to polymer and stirring speed on (e) particle size (fixed ratio of organic to aqueous phase = 7.5:1).
