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. 2017 Dec 23;25(1):143–152. doi: 10.1080/10717544.2017.1419514

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (a) The in vitro release profile of RM from microspheres prepared by W/O/W double emulsion–solvent evaporation method (MS-B) and W/O/O emulsion-phase separation method with the drug loading of 7.20% (MS-E1), 17.34% (MS-E2), 26.42% (MS-E3) and 30.12% (MS-optimal formulation). (b) and (c) The effect of solvent type and volume in gel matrix solution on the in vitro release of RM-microsphere-Gel in situ forming implant, 15% EtOH (S1), 20% EtOH (S2), 25% EtOH (S3), 25% NMP (S4), 30% NMP (S5), 40% NMP (S6). (d) The in vitro release profile of RM from in situ gel with the solvent of 15% EtOH (S7) and 25% NMP (S8). Graphs symbolize mean ± SD. (n = 3).