Table 6.

Research priorities

Patient selection research priorities

Standardization of core, mismatch and collaterals definitions

Standardizing acceptable methods and imaging parameters within and across modalities Comparability of NCCT ASPECTS, DWI, PCT volume estimates and thresholds, collateral scores on multi-phase or single-phase CTA Equivalent definitions and thresholds of mismatch across modalities including coregistration methods between core and perfusion imaging in order to precisely measure the mismatch volume Acceptable variability, i.e. inter-rater reliability, centralized review versus individual site review Defining futility thresholds Validation of semi-automated methods or fully automated methods of image quantification across vendor platforms, devices and modalities

Final infarct volume research priorities

Recommended as outcome measure at Phase II to assess biological effect of therapy Comparison to baseline core volume preferred (volume of change or statistical adjustment) Acceptable variability, i.e. inter-rater reliability, centralized review versus individual site review Optimal timing and modality/sequence Correction for edema, shift due to mass effect, hemorrhagic transformation, atrophy and pre-existing chronic lesions