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. 2018 Jan 15;25(1):293–306. doi: 10.1080/10717544.2018.1425779

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Anticancer activity and the selective cellular uptake of Ru@MSNs in vitro. The drug concentration in all biological studies was calculated as RuPOP by ICP-MS analysis. (a) IC₅₀ for the RuPOP and different-sized Ru@MSNs toward HepG2 tumor cells and L02 normal cells. Cellular uptake of different-sized Ru@MSNs in HepG2 (b) and L02 (c) cells for 4 and 8 h. Cells were treated with 1 μM of different-sized Ru@MSNs and free RuPOP. (d) Localization of the different-sized Ru@MSNs (red) in HepG2 cells. The cells were treated with 1 μM of Ru@MSNs. (e), (f), and (g) in vitro drug release for the different-sized Ru@MSNs in PBS at pH =7.4 and cells lysate. The scale bar is 20 μm. Value represents means ± SD (n = 3).