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. 2018 Jan 15;25(1):293–306. doi: 10.1080/10717544.2018.1425779

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (a) Flow cytometric analysis of HepG2 cells (2 × 10⁴ cells/mL) exposed with 0.2 μM of different-sized Ru@MSNs for 24 h. (b) ROS overproduction in HepG2 cells (2 × 10⁵ cells/mL) exposed to RuPOP and Ru@MSNs (1 μM) for 2 h. (c) Immunofluorescence of phosphorylated p53 in HepG2 cells with different-sized Ru@MSNs and free RuPOP at 1 μM. The scale bar is 20 μm. Value represents means ± SD (n = 3). (d) Activation of p53 signal pathway in HepG2 cells exposed to different-sized Ru@MSNs. (e) Fluorescence imaging monitor the accumulation and distribution of the different-sized Ru@MSNs in HepG2 xenograft nude mice at 72 h. The treated concentration was 0.2 mg/kg of Ru@MSNs. (f) Fluorescence imaging of the main organs in 72 h-treatment with Ru@MSNs and free RuPOP.