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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Cancer Discov. 2018 Mar 21;8(6):750–763. doi: 10.1158/2159-8290.CD-17-1368

Figure. 1. RM GFP and CD20 CAR T cell product composition and function.

Figure. 1

A, GFP and EGFRt expression in RM T cell products transduced with GFP (R.301 GFP, green) or CD20 CAR (R.301–R.304 EGFRt, red); Mock (blue). CD8 and CD4 composition in RM GFP+ (R.301 GFP+) or EGFRt+ T cell products (R.301–R.304 EGFRt+). B, Composition of T cells in CD20 CAR products in EGFRt+ (top) and EGFRt− (bottom) CD4 and CD8 cells (R.301–R.304, n = 4). CD28+/CD95+: central memory, CD28−/CD95+: effector memory and CD28+/CD95−: naive T cells. Horizontal lines represent the mean. C, CD20 antigen expression in human (K562 and CD20-K562), and in RM (B-LCL1 and B-LCL2) cell lines. Cytolytic activity of RM mock-transduced (dashed lines) and CD20 CAR T cells (solid lines) against 51Cr-labeled targets (K562, CD20-K562, B-LCL1 and B-LCL2). n = 3 replicates per point; representative of four recipients.