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Pharmacodynamics parameters after single subcutaneous injection of free insulin solution and gastric gavage with saline and the nanoparticles (n = 5).
| Group | INS dose (IU/kg) | Method | BGLmin (%) | PT-70% (h) | AAC0-24a | PA (%) |
|---|---|---|---|---|---|---|
| Insulin | 3 | s.c. | 37.2 | 2.7 | 304.0 | 100 |
| INS/HTCC-CA | 30 | i.g. | 75.6 | – | 220.9 | 7.3 |
| INS/HTCC/HPMCP | 30 | i.g. | 71.9 | – | 341.2 | 11.2 |
| INS/HTCC-CA/HPMCP | 30 | i.g. | 54.1 | 20.0 | 817.9 | 26.9 |
The area above the curve shown in Figure 5(A) during 0–24 h.
