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HepG2 cellular apoptosis induced by NP-SFB-Ab. In HepG2 cells treated with NP-SFB-Ab for 24 hours, the expression of antiapoptotic proteins XIAP and C-FLIP was not affected by western blot analysis, but Mcl-1 was inhibited to a certain extent; the levels of Bak and Bax on mitochondrial membrane were up-regulated; meanwhile, the expressions of apoptosis related proteins (hydrolyzed caspase-3, -8 and cytochrome c) were significantly up-regulated.
