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. 2018 Jan 15;25(1):256–266. doi: 10.1080/10717544.2018.1425777

Figure 4.

Figure 4.

(A) Plasma concentrations of TPL in normal Sprague-Dawley rats that received endotracheal administration of different TPL formulations at a TPL dose of 0.5 mg/kg (n = 4, mean ± SD). (B) Changes in tumor burden monitored by the IVIS Lumina XR system (n = 5, mean ± SEM); Arrows indicate time of administration (on day 7, 13, 19, 25); **p < .01, ***p < .001, compared with saline. (C) Changes in body weight of orthotopic lung tumor bearing mice. (D) Representative bioluminescent images and corresponding lung tissue of the mice at day 31 after tumor inoculation.