Table 2.

The pharmacokinetic parameters of different TPL formulations after endotracheal administration (0.5 mg/kg) in mice (n = 4).

Parameters	Unit	Free TPL	TPL-lip	CA IX-TPL-lip	CPP33-TPL-lip	dl-TPL-lip
AUC(0–t)	μg/L*h	185.89 ± 36.48	84.28 ± 10.60	126.02 ± 12.20	68.33 ± 27.41	131.54 ± 10.46
AUC(0–∞)	μg/L*h	224.87 ± 63.76	228.74 ± 67.72	191.83 ± 89.75	125.01 ± 76.18	244.54 ± 63.02
t1/2	H	2.98 ± 0.54	9.74 ± 5.68	6.39 ± 3.97	7.68 ± 9.68	9.96 ± 6.63
Tmax	h	0.083	0.083	0.083	0.083	0.083
Cmax	μg/L	188.17 ± 42.71	32.56 ± 9.37	46.25 ± 11.96	57.71 ± 32.15	41.55 ± 16.42